(19)

(11)

EP 0 830 057 A1

(12)

(43) Date of publication: 25.03.1998 Bulletin 1998/13 (21) Application number: 96916996.0 (22) Date of filing: 03.06.1996

(51) International Patent Classification (IPC):  C12N 13/ 00( . ) A61K 35/ 14( . ) A61L 2/ 00( . ) C12N 7/ 04( . ) A61K 35/ 12( . ) A61K 41/ 00( . ) A61L 2/ 08( . ) (86) International application number: PCT/US1996/008421 (87) International publication number: WO 1996/039816 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 07.06.1995 US 19950480271 07.06.1995 US 19950474459 (71) Applicant: BAXTER INTERNATIONAL INC. Deerfield, Illinois 60015 (US)	(72) Inventors: SOWEMIMO-COKER, Samuel, O. Arcadia, CA 91006 (US) YERRAM, Nagender South Pasadena, CA 91036 (US) GOODRICH, Raymond, P., Jr. Pasadena, CA 91107 (US) PLATZ, Matthew Columbus, OH 43235 (US) PARK, Sang, Chul Arcadia, CA 91007 (US) (74) Representative: MacGregor, Gordon, et al  ERIC POTTER CLARKSON St. Mary's Court St. Mary's Gate Nottingham, NG1 1LE Nottingham, NG1 1LE (GB)