(19)

(11)

EP 0 830 133 A1

(12)

(43) Date of publication: 25.03.1998 Bulletin 1998/13 (21) Application number: 96912213.0 (22) Date of filing: 24.04.1996

(51) International Patent Classification (IPC):  A61K 45/ 06( . ) (86) International application number: PCT/JP1996/001102 (87) International publication number: WO 1996/033717 (31.10.1996 Gazette 1996/48)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 28.04.1995 JP 19950106316 19.10.1995 JP 19950270856 (71) Applicant: Takeda Chemical Industries, Ltd. Osaka-shi, Osaka 541 (JP)	(72) Inventors: MAKINO, Haruhiko Hyogo 666-02 (JP) SOHDA, Takashi Osaka 569 (JP) (74) Representative: von Kreisler, Alek, Dipl.-Chem., et al  Patentanwälte, von Kreisler-Selting-Werner, Bahnhofsvorplatz 1 (Deichmannhaus) 50667 Köln 50667 Köln (DE)