(19)

(11)

EP 0 830 449 A1

(12)

(43) Date of publication: 25.03.1998 Bulletin 1998/13 (21) Application number: 96921518.0 (22) Date of filing: 07.06.1996

(51) International Patent Classification (IPC):  G01N 33/ 92( . ) C12Q 1/ 04( . ) C12Q 1/ 02( . ) G01N 33/ 569( . ) (86) International application number: PCT/US1996/010040 (87) International publication number: WO 1996/040869 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950487188 06.06.1996 US 19960659369 (71) Applicant: THE UNIVERSITY OF CONNECTICUT Storrs, Connecticut 06269-1133 (US)	(72) Inventors: KRIDER, Hallie, M. Willimantic, CT 06226 (US) BUSHMICH, Sandra, Lee Hebron, CT 06248 (US) (74) Representative: Harding, Charles Thomas  D. Young & Co. 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)