(19)

(11)

EP 0 831 708 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96916683.0 (22) Date of filing: 30.05.1996

(51) International Patent Classification (IPC):  C12P 13/ 00( . ) A01N 63/ 00( . ) C12N 1/ 20( . ) C12R 1/ 07( . ) A01N 47/ 28( . ) A01N 63/ 02( . ) C12N 15/ 00( . ) (86) International application number: PCT/US1996/007807 (87) International publication number: WO 1996/039037 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.06.1995 US 19950470289 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: MANKER, Denise, C. Davis, CA 95616 (US) LIDSTER, William, D. Sacramento, CA 95819 (US) MACINTOSH, Susan, C. Woodland, CA 95695 (US) STARNES, Robert, L. Sacramento, CA 95825 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)