(19)

(11)

EP 0 831 762 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96917114.0 (22) Date of filing: 04.06.1996

(51) International Patent Classification (IPC):  A61K 8/ 00( . ) A61K 8/ 33( . ) A61K 8/ 40( . ) A61K 8/ 86( . ) A61K 8/ 891( . ) A61Q 1/ 00( . ) A61Q 11/ 00( . ) A61K 8/ 06( . ) A61K 8/ 34( . ) A61K 8/ 49( . ) A61K 8/ 89( . ) A61K 8/ 90( . ) A61Q 1/ 04( . ) C08L 83/ 04( . ) (86) International application number: PCT/US1996/008714 (87) International publication number: WO 1996/039116 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.06.1995 US 19950461698 05.06.1995 US 19950462203 05.06.1995 US 19950462599 05.06.1995 US 19950462930 05.06.1995 US 19950464403 (71) Applicant: WHITEHILL ORAL TECHNOLOGIES INC. Chadds Ford, PA 19317 (US)	(72) Inventors: HILL, Ira, D. Locust, NJ 07760 (US) WALTERS, Peter, P. Neshanic, NJ 08853 (US) BROWN, Dale, G. Wharton, TX 77488 (US) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK, 57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)