(19)

(11)

EP 0 831 771 A2

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96918287.0 (22) Date of filing: 07.06.1996

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) A61K 35/ 76( . ) A61P 1/ 00( . ) A61P 37/ 04( . ) A61K 9/ 48( . ) A61K 48/ 00( . ) A61P 9/ 00( . ) (86) International application number: PCT/US1996/009371 (87) International publication number: WO 1996/040081 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 07.06.1995 US 19950475961 (71) Applicant: ALZA CORPORATION Palo Alto California 94303-0802 (US)	(72) Inventors: DADDONA, Peter, E. Menlo Park, CA 94025 (US) DE CHADAREVIAN, Gamil, G. I-00135 Rome (IT) FIX, Joseph, A. Half Moon Bay, CA 94019 (US) GARDNER, Phyllis, I. Stanford, CA 94305 (US) ROSEN, Howard, B. Los Gatos, CA 95030 (US) (74) Representative: Stebbing, Peter John Hunter, et al  Ablett & Stebbing 45 Lancaster Mews Lancaster Gate London W2 3QQ London W2 3QQ (GB)