(19)

(11)

EP 0 831 842 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96916782.0 (22) Date of filing: 30.05.1996

(51) International Patent Classification (IPC):  A61K 31/ 66( . ) (86) International application number: PCT/US1996/008029 (87) International publication number: WO 1996/039148 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.06.1995 US 19950468298 (71) Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA Los Angeles, CA 90089 (US)	(72) Inventor: McKENNA, Charles, E. Pacific Palisades, CA 90272 (US) (74) Representative: Orès, Bernard, et al  Cabinet ORES 6, Avenue de Messine 75008 Paris 75008 Paris (FR)