OLIGONUCLEOTIDES HAVING PHOSPHOROTHIOATE LINKAGES OF HIGH CHIRAL PURITY

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EP 0 831 854 A1

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(43)	Date of publication:
	01.04.1998 Bulletin 1998/14

(21)	Application number: 96921270.0

(22)	Date of filing: 05.06.1996

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International Patent Classification (IPC):

C12N 15/ 09^{( . )}
A61K 31/ 7088^{( . )}
A61K 48/ 00^{( . )}
A61P 25/ 00^{( . )}
A61P 29/ 00^{( . )}
A61P 31/ 14^{( . )}
A61P 35/ 00^{( . )}
C07H 21/ 00^{( . )}
C12N 15/ 113^{( . )}

A61K 31/ 70^{( . )}
A61K 31/ 7125^{( . )}
A61P 1/ 16^{( . )}
A61P 27/ 02^{( . )}
A61P 31/ 12^{( . )}
A61P 31/ 18^{( . )}
A61P 43/ 00^{( . )}
C07H 21/ 04^{( . )}

(86)	International application number:
	PCT/US1996/008757

(87)	International publication number:
	WO 1996/039154 (12.12.1996 Gazette 1997/02)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

06.06.1995 US 19950471967
06.06.1995 US 19950467597
06.06.1995 US 19950468447
06.06.1995 US 19950468569
06.06.1995 US 19950466692
06.06.1995 US 19950471966
06.06.1995 US 19950469851
06.06.1995 US 19950470129

(71)	Applicant: ISIS PHARMACEUTICALS, INC.
	Carlsbad, CA 92008 (US)

(72)	Inventors:
	COOK, Phillip, Dan Vista, CA 92084 (US) HOKE, Glenn Mt. Airy, MD 21771 (US)

(74)	Representative: Hallybone, Huw George, et al
	CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)

(54)	OLIGONUCLEOTIDES HAVING PHOSPHOROTHIOATE LINKAGES OF HIGH CHIRAL PURITY