(19)

(11)

EP 0 831 866 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 95922956.0 (22) Date of filing: 05.06.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 31/ 70( . ) A61K 38/ 22( . ) A61P 5/ 00( . ) C07K 14/ 575( . ) C12N 5/ 10( . ) C12Q 1/ 68( . ) A61K 31/ 00( . ) A61K 31/ 7088( . ) A61K 48/ 00( . ) C07K 14/ 47( . ) C07K 14/ 705( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1995/007067 (87) International publication number: WO 1996/039158 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: HE, Wei Wu Columbia, MD 21045 (US) ROSEN, Craig A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)