(19)

(11)

EP 0 831 872 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96920441.0 (22) Date of filing: 23.05.1996

(51) International Patent Classification (IPC):  C07K 7/ 08( . ) C12N 9/ 16( . ) A61K 38/ 00( . ) C07K 14/ 00( . ) C12N 9/ 24( . ) (86) International application number: PCT/US1996/007564 (87) International publication number: WO 1996/037212 (28.11.1996 Gazette 1996/52)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 26.05.1995 US 19950452043 (71) Applicant: TORREY PINES INSTITUTE FOR MOLECULAR STUDIES San Diego, CA 92121 (US)	(72) Inventors: BLONDELLE, Sylvie, E. San Diego, CA 92130 (US) PEREZ-PAYA, Enrique San Diego, CA 92122 (US) FOROOD, Behrouz San Diego, CA 92122 (US) HOUGHTEN, Richard, A. Del Mar, CA 92014 (US) (74) Representative: Voelker, Ingeborg Carla Emmy  Uexküll & Stolberg Patentanwälte Beselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)