(19)

(11)

EP 0 831 874 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96921461.0 (22) Date of filing: 07.06.1996

(51) International Patent Classification (IPC):  A61K 38/ 17( . ) C12N 15/ 861( . ) A61K 48/ 00( . ) (86) International application number: PCT/US1996/009858 (87) International publication number: WO 1996/040195 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: DE ES FR GB IT (30) Priority: 07.06.1995 US 19950481122 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94612-3550 (US)	(72) Inventors: GIORDANO, Frank, J. Del Mar, CA 92014 (US) DILLMANN, Wolfgang, H. Solana Beach, CA 92075 (US) MESTRIL, Ruben San Diego, CA 92111 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)