(19)

(11)

EP 0 831 875 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96923327.0 (22) Date of filing: 07.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) A61K 48/ 00( . ) A61P 29/ 00( . ) C07K 14/ 735( . ) C12N 15/ 113( . ) A61K 31/ 70( . ) A61K 38/ 17( . ) A61K 45/ 00( . ) A61P 11/ 00( . ) A61P 37/ 06( . ) C12N 5/ 10( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1996/010494 (87) International publication number: WO 1996/040199 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950483530 (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA Philadelphia, Pennsylvania 19104-3147 (US)	(72) Inventors: SCHREIBER, Alan D. Philadelphia, PA 19119 (US) PARK, Jong-Gu Drexel Hill, PA 19026 (US) (74) Representative: Harding, Charles Thomas  D. Young & Co. 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)