(19)

(11)

EP 0 831 880 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96921457.0 (22) Date of filing: 07.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 31/ 65( . ) A61K 38/ 00( . ) A61K 45/ 00( . ) C07K 7/ 06( . ) C07K 16/ 28( . ) C12N 5/ 10( . ) A61K 31/ 335( . ) A61K 33/ 24( . ) A61K 39/ 395( . ) A61P 35/ 00( . ) C07K 7/ 08( . ) C07K 16/ 46( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1996/009847 (87) International publication number: WO 1996/040210 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV SI (30) Priority: 07.06.1995 US 19950482982 15.12.1995 US 19950573289 (71) Applicant: IMCLONE SYSTEMS, INC. New York, NY 10014 (US)	(72) Inventors: GOLDSTEIN, Neil I. Maplewood, NJ 07040 (US) GIORGIO, Nicholas A. New York, NY 10004 (US) JONES, Steven Tarran Radlett Hertfordshire WD7 8HA (GB) SALDANHA, Jose William Enfield Middlesex EN1 1TE (GB) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)