(19)

(11)

EP 0 831 922 A2

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96917590.0 (22) Date of filing: 10.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 48/ 00( . ) C07K 14/ 025( . ) C07K 14/ 16( . ) C07K 16/ 28( . ) C12N 15/ 87( . ) A61K 47/ 48( . ) C07K 14/ 005( . ) C07K 14/ 11( . ) C07K 14/ 47( . ) C12N 7/ 04( . ) (86) International application number: PCT/GB1996/001396 (87) International publication number: WO 1996/041606 (27.12.1996 Gazette 1997/04)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV SI (30) Priority: 08.06.1995 US 19950000124 30.06.1995 GB 19950013399 21.09.1995 GB 19950019304 25.09.1995 US 19950004285 19.12.1995 GB 19950025955 19.12.1995 US 19950600895 12.02.1996 US 19960011531 07.06.1996 US 19960660231 (71) Applicant: Therexsys Limited Keele, Staffordshire ST5 5SP (GB)

(72) Inventors: THATCHER, David, Robert Macclesfield SK10 4XT (GB) CRAIG, Roger, Kingdon Sandbach, Cheshire CW11 0XA (GB) WILKS, Paula, Elizabeth Stoke on Trent ST7 2JK (GB) CUNLIFFE, Vincent, Trevor Knutsford WA16 6HZ (GB) WELSH, John, Hamilton Newcastle under Lyme ST5 4HJ (GB) (74) Representative: Hallybone, Huw George  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)