(19)

(11)

EP 0 831 931 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96920342.0 (22) Date of filing: 21.05.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 49/ 00( . ) C12N 15/ 85( . ) A01K 67/ 027( . ) C12N 5/ 10( . ) C12Q 1/ 02( . ) (86) International application number: PCT/US1996/007337 (87) International publication number: WO 1996/037237 (28.11.1996 Gazette 1996/52)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.05.1995 US 19950449826 16.06.1995 US 19950000280P (71) Applicant: THOMAS JEFFERSON UNIVERSITY Philadelphia Pennsylvania 19107 (US)	(72) Inventors: BERNSTEIN, Eric Wynnewood, PA 19096 (US) UITTO, Jouni Gladwyne, PA 19035 (US) (74) Representative: Stebbing, Peter John Hunter, et al  Ablett & Stebbing 45 Lancaster Mews Lancaster Gate London W2 3QQ London W2 3QQ (GB)