(19)

(11)

EP 0 832 060 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96922607.0 (22) Date of filing: 07.06.1996

(51) International Patent Classification (IPC):  C07C( . ) A61K 31/ 00( . ) A61K 31/ 165( . ) A61K 31/ 195( . ) A61K 31/ 245( . ) C07C 233/ 25( . ) C07C 235/ 84( . ) C07C 237/ 42( . ) A61K 45/ 00( . ) A61K 31/ 16( . ) A61K 31/ 167( . ) A61K 31/ 235( . ) A61P 35/ 00( . ) C07C 235/ 56( . ) C07C 237/ 40( . ) (86) International application number: PCT/US1996/011018 (87) International publication number: WO 1996/040620 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV SI (30) Priority: 07.06.1995 US 19950475573 (71) Applicant: THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES Xuan Wu Dist., Beijing 100050 (CN)	(72) Inventors: HAN, Rui Beijing 100078 (CN) GUO, Zong-Ru Beijing 100078 (CN) (74) Representative: Wiklund, Ingrid Helena  AWAPATENT AB, Box 5117 200 71 Malmö 200 71 Malmö (SE)