(19)

(11)

EP 0 832 117 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96921319.0 (22) Date of filing: 05.06.1996

(51) International Patent Classification (IPC):  C07K 14/ 47( . ) C07K 14/ 82( . ) A61K 38/ 00( . ) C07K 14/ 72( . ) C12N 15/ 10( . ) A61K 39/ 00( . ) (86) International application number: PCT/US1996/009194 (87) International publication number: WO 1996/039427 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.06.1995 US 19950463074 05.06.1995 US 19950462337 05.06.1995 US 19950462390 05.06.1995 US 19950465585 05.06.1995 US 19950463081 05.06.1995 US 19950461379 (71) Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE Hanover, NH 03755-3580 (US)	(72) Inventors: SMITH, Kendall, A. New York, NY 10128 (US) BEADLING, Carol New York, NY 10021 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)