(19)

(11)

EP 0 832 190 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96918335.0 (22) Date of filing: 06.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 31/ 70( . ) A61K 48/ 00( . ) A61P 43/ 00( . ) C12N 5/ 10( . ) C12Q 1/ 48( . ) A61K 38/ 00( . ) A01K 67/ 027( . ) A61K 38/ 43( . ) A61P 35/ 00( . ) C12N 1/ 21( . ) C12N 9/ 12( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1996/009517 (87) International publication number: WO 1996/040868 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950478352 (71) Applicant: COLD SPRING HARBOR LABORATORY Cold Spring Harbor, NY 11724 (US)	(72) Inventors: GREIDER, Carol Huntington, NY 11743 (US) AUTEXIER, Chantal East Northport, NY 11731 (US) (74) Representative: Price, Vincent Andrew, et al  FRY HEATH & SPENCE The Old College 53 High Street Horley Surrey RH6 7BN Horley Surrey RH6 7BN (GB)