(19)

(11)

EP 0 832 197 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96924336.0 (22) Date of filing: 04.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 17( . ) C12N 7/ 00( . ) C12N 15/ 863( . ) A61K 39/ 00( . ) A61P 31/ 12( . ) C12N 7/ 01( . ) C12R 1/ 92( . ) (86) International application number: PCT/US1996/011187 (87) International publication number: WO 1996/040880 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950484790 (71) Applicant: SYNTRO CORPORATION Lenexa Kansas 66219 (US)	(72) Inventors: COCHRAN, Mark, D. Carlsbad, CA 92008 (US) JUNKER, David, E. San Diego, CA 92120 (US) SINGER, Philip, A. San Diego, CA 92117 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)