(19)

(11)

EP 0 832 209 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96918107.0 (22) Date of filing: 04.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 15/ 10( . ) C12P 21/ 02( . ) C12N 5/ 10( . ) C12N 15/ 62( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1996/008936 (87) International publication number: WO 1996/040904 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950483493 07.06.1995 US 19950472806 (71) Applicant: ZymoGenetics, Inc. Seattle Washington 98102 (US)	(72) Inventor: LOK, Si Seattle, WA 98107 (US) (74) Representative: Bizley, Richard Edward, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Baker's Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)