(19)

(11)

EP 0 832 216 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 95922978.0 (22) Date of filing: 05.06.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 395( . ) A61K 48/ 00( . ) A61P 9/ 08( . ) A61P 25/ 00( . ) A61P 35/ 00( . ) C07K 14/ 50( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) A61K 38/ 00( . ) A61K 38/ 22( . ) A61K 45/ 00( . ) A61P 7/ 02( . ) A61P 9/ 10( . ) A61P 25/ 28( . ) A61P 43/ 00( . ) C07K 16/ 22( . ) C12N 15/ 00( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1995/007156 (87) International publication number: WO 1996/039509 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: GREENE, John, M. Gaithersburg, MD 20878 (US) ROSEN, Craig, A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)