(19)
(11) EP 0 832 223 A1

(12)

(43) Date of publication:
01.04.1998 Bulletin 1998/14

(21) Application number: 96918669.0

(22) Date of filing: 04.06.1996
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
A61K 39/ 395( . )
A61P 37/ 00( . )
C07K 7/ 06( . )
C07K 16/ 18( . )
C12N 5/ 10( . )
C12N 15/ 12( . )
C12P 21/ 08( . )
G01N 33/ 566( . )
 A61K 38/ 00( . )
A61P 29/ 00( . )
C07K 1/ 107( . )
C07K 14/ 47( . )
C12N 1/ 21( . )
C12N 15/ 02( . )
C12P 21/ 02( . )
G01N 33/ 53( . )
(86) International application number:
PCT/EP1996/002422
(87) International publication number:
WO 1996/039503 (12.12.1996 Gazette 1997/02)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 05.06.1995 US 19950463224
05.06.1995 US 19950463377
05.06.1995 US 19950462648

(71) Applicant: Novartis AG
4058 Basel (CH)

(72) Inventors:
  • VAN OOSTRUM, Jan
    CH-4112 Flüh (CH)
  • VAN HEEKE, Gino
    Upper Beeding BN44 3HP (GB)
  • SCHMITZ, Albert
    CH-4056 Basle (CH)

(74) Representative: Roth, Bernhard M., et al 
Novartis AG Geistiges Eigentum Konzern Patent- und Markenabteilung CH Postfach
4002 Basel
4002 Basel (CH)

   


(54) C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY AND METHODS FOR PREPARATION