(19)

(11)

EP 0 832 231 A2

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96922382.0 (22) Date of filing: 03.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 37/ 00( . ) C07K 14/ 47( . ) C07K 16/ 28( . ) C12N 9/ 64( . ) C12N 15/ 12( . ) C12P 21/ 08( . ) G01N 33/ 53( . ) A61K 31/ 70( . ) A61K 39/ 395( . ) A61P 35/ 00( . ) A61P 43/ 00( . ) C07K 14/ 705( . ) C12N 1/ 21( . ) C12N 15/ 10( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1996/008596 (87) International publication number: WO 1996/039511 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: BE DE ES FR GB IT NL (30) Priority: 05.06.1995 US 19950462355 (71) Applicant: INCYTE PHARMACEUTICALS, INC. Palo Alto , CA 94304 (US)	(72) Inventors: COLEMAN, Roger Mountain View, CA 94041 (US) AU-YOUNG, Janice Berkeley, CA 94702 (US) BANDMAN, Olga Mountain View, CA 94043 (US) SEILHAMER, Jeffrey, J. Los Altos Hills, CA 94022 (US) (74) Representative: Wright, Simon Mark, et al  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)