(19)

(11)

EP 0 832 269 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96915344.0 (22) Date of filing: 23.04.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 48/ 00( . ) C12N 5/ 10( . ) A61K 47/ 48( . ) C07K 14/ 00( . ) C12N 15/ 87( . ) (86) International application number: PCT/US1996/005679 (87) International publication number: WO 1996/040958 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950484777 (71) Applicant: BAYLOR COLLEGE OF MEDICINE Houston, TX 77030-3498 (US)	(72) Inventors: SMITH, Louis, C. Houston, TX 77098 (US) SPARROW, James, T. Houston, TX 77035 (US) WOO, Savio, L., C. Houston, TX 77096 (US) (74) Representative: Moon, Donald Keith, et al  BREWER & SON Quality House Quality Court Chancery Lane London WC2A 1HT London WC2A 1HT (GB)