(19)
(11) EP 0 832 271 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
02.03.2005 Bulletin 2005/09

(45) Mention of the grant of the patent:
22.12.2004 Bulletin 2004/52

(21) Application number: 96922432.8

(22) Date of filing: 06.06.1996
(51) International Patent Classification (IPC)7C12N 15/87, C12N 15/88, A61K 48/00, A61K 9/127
(86) International application number:
PCT/US1996/009949
(87) International publication number:
WO 1996/040964 (19.12.1996 Gazette 1996/55)

(54)

LIPID-NUCLEIC ACID PARTICLES PREPARED VIA A HYDROPHOBIC LIPID-NUCLEIC ACID COMPLEX INTERMEDIATE AND USE FOR GENE TRANSFER

HERSTELLUNG VON LIPID-NUKLEINSÄURE PARTIKELN DUCH EIN HYDROPHOBISCHE LIPID-NUKLEINSÄUREE KOMPLEXE ZWISCHENPRODUKT UND ZUR VERWENDUNG IN DER GENTRANSFER

PARTICULES D'ACIDES NUCLEIQUES ET DE LIPIDES PREPAREES AU MOYEN D'UN INTERMEDIAIRE DE COMPLEXE HYDROPHOBE D'ACIDES NUCLEIQUES ET DE LIPIDES ET UTILISATION POUR TRANSFERER DES GENES


(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 07.06.1995 US 484282
07.06.1995 US 485458

(43) Date of publication of application:
01.04.1998 Bulletin 1998/14

(60) Divisional application:
04022700.1 / 1489184

(73) Proprietor: INEX Pharmaceuticals Corp.
Vancouver B.C. V6P 6P2 (CA)

(72) Inventors:
  • WHEELER, Jeffery, J.
    Vancouver, British Columbia V6P 2Y8 (CA)
  • BALLY, Marcel, B.
    Bowen Island, British Columbia V0N 1G0 (CA)
  • ZHANG, Yuan-Peng
    Vancouver, British Columbia V5T 2B8 (CA)
  • REIMER, Dorothy, L.
    Vancouver, British Columbia V5T 4J4 (CA)
  • HOPE, Michael
    Vancouver, British Columbia V6R 2K2 (CA)
  • CULLIS, Pieter, R.
    Vancouver, British Columbia V6R 1H4 (CA)
  • SCHERRER, Peter
    Vancouver, British Columbia V6H 2T5 (CA)

(74) Representative: Finsterwald, Martin et al
Manitz, Finsterwald & Partner GbR Martin-Greif-Strasse 1
80336 München
80336 München (DE)


(56) References cited: : 
WO-A-91/16024
WO-A-93/12756
WO-A-93/25673
WO-A-95/18863
WO-A-96/02655
WO-A-96/41873
US-A- 5 279 833
US-A- 5 578 475
US-A- 5 656 743
WO-A-93/12240
WO-A-93/24640
WO-A-95/02698
WO-A-95/35301
WO-A-96/10390
US-A- 5 208 036
US-A- 5 283 185
US-A- 5 641 662
US-A- 5 703 055
   
  • R. CORTESI ET AL.: "Effect of cationic liposome composition on in vitro cytotoxicity and protective effect on carried DNA." INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 139, no. 1,2, 9 August 1996 (1996-08-09), pages 69-78, XP000874084
  • GAY-CAFFEY J K ET AL: "NOVEL POLYAMINOLIPIDS ENHANCE TH CELLULAR UPTAKE OF OLIGONUCLEOTIDES" JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 270, no. 52, 29 December 1995 (1995-12-29), pages 31391-31396, XP002017298 ISSN: 0021-9258
  • WOUDE VAN DER I ET AL: "PARAMETERS INFLUENCING THE INTRODUCTION OF PLASMID DNA INTO CELLS BY THE USE OF SYNTHETIC AMPHIPHILES AS A CARRIER SYSTEM" BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES,NL,AMSTERDAM, vol. 1240, no. 1, 1 January 1995 (1995-01-01), pages 34-40, XP000600703 ISSN: 0005-2736
  • DWARKI V J ET AL: "CATIONIC LIPOSOME-MEDIATED RNA TRANSFECTION" METHODS IN ENZYMOLOGY,US,ACADEMIC PRESS INC, SAN DIEGO, CA, vol. 217, 1 January 1993 (1993-01-01), pages 644-654, XP000600710 ISSN: 0076-6879
  • FELGNER J ET AL: "CATIONIC LIPID-MEDIATED TRANSFECTION IN MAMMALIAN CELLS: LIPOFECTION" JOURNAL OF TISSUE CULTURE METHODS,NL,KLUWER ACADEMIC PUBLISHERS, AMSTERDAM, vol. 15, no. 2, 1 January 1993 (1993-01-01), pages 63-68, XP000600638 ISSN: 0271-8057
  • FELGNER P L ET AL: "CATIONIC LIPOSOME MEDIATED TRANSFECTION" WESTERN PHARMACOLOGY SOCIETY. PROCEEDINGS,US,WESTERN PHARMACOLOGY SOCIETY, TUCSON, AZ, vol. 32, 1 January 1989 (1989-01-01), pages 115-121, XP000196640 ISSN: 0083-8969
  • FELGNER J H ET AL: "ENHANCED GENE DELIVERY AND MECHANISM STUDIES WITH A NOVEL SERIES OF CATIONIC LIPID FORMULATIONS" JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 269, no. 4, 28 January 1994 (1994-01-28), pages 2550-2561, XP002010485 ISSN: 0021-9258
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).