(19)

(11)

EP 0 832 282 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96917035.0 (22) Date of filing: 03.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 705( . ) C12N 15/ 10( . ) A61K 38/ 00( . ) C12R 1/ 19( . ) C07K 14/ 47( . ) C12N 9/ 64( . ) C12Q 1/ 68( . ) A61K 48/ 00( . ) (86) International application number: PCT/US1996/008501 (87) International publication number: WO 1996/038591 (05.12.1996 Gazette 1997/01)

(84) Designated Contracting States: BE DE ES FR GB IT NL (30) Priority: 02.06.1995 US 19950459046 05.06.1995 US 19950462355 07.06.1995 US 19950487112 15.11.1995 US 19950006809 01.12.1995 US 19950566334 (71) Applicant: INCYTE PHARMACEUTICALS, INC. Palo Alto , CA 94304 (US)	(72) Inventor: GUEGLER, Karl, J. Menlo Park, CA 94025 (US) (74) Representative: Wright, Simon Mark, et al  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)