(19)

(11)

EP 0 832 295 A1

(12)

(43) Date of publication: 01.04.1998 Bulletin 1998/14 (21) Application number: 96921406.0 (22) Date of filing: 06.06.1996

(51) International Patent Classification (IPC):  C07K 14/ 51( . ) C12N 15/ 12( . ) G01N 33/ 50( . ) C07K 14/ 71( . ) C12Q 1/ 68( . ) G01N 33/ 567( . ) (86) International application number: PCT/US1996/009638 (87) International publication number: WO 1996/041013 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: CH DE FR GB IT LI NL (30) Priority: 07.06.1995 US 19950482436 (71) Applicant: LIGAND PHARMACEUTICALS INCORPORATED San Diego, California 92121 (US)	(72) Inventors: McDONNELL, Donald P. San Diego, CA 92131 (US) DELORME, Evelyn San Diego, CA 92122 (US) MINER, Jeffrey N. San Diego, CA 92122 (US) GLEESON, Martin A.G. San Diego, CA 92130 (US) WEN, Xiaohong Dawn San Diego, CA 92122 (US) PIKE, J.Wesley Encinitas, CA 92024 (US) (74) Representative: Viering, Jentschura & Partner  Postfach 22 14 43 80504 München 80504 München (DE)