(19)

(11)

EP 0 833 608 A2

(12)

(43) Date of publication: 08.04.1998 Bulletin 1998/15 (21) Application number: 96919114.0 (22) Date of filing: 05.06.1996

(51) International Patent Classification (IPC):  A61K 9/ 107( . ) A61K 9/ 113( . ) A61K 9/ 00( . ) (86) International application number: PCT/US1996/009064 (87) International publication number: WO 1996/040057 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950487612 (71) Applicant: ALLIANCE PHARMACEUTICAL CORPORATION San Diego California 92121 (US)

(72) Inventors: TARARA, Thomas, E. San Diego, CA 92102 (US) WEERS, Jeffry, G. San Diego, CA 92129 (US) TREVINO, Leo, A. San Diego, CA 92122 (US) KABALNOV, Alexey San Diego, CA 92130 (US) DELLAMARY, Luis, A. San Marcos, CA 92069 (US) HOPPER, Gina, M. Escondido, CA 92037 (US) RANNEY, Helen, M. La Jolla, CA 92037 (US) KLEIN, David, H. Carlsbad, CA 92008 (US) PELURA, Timothy, J. San Diego, CA 92131 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)