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(11)

EP 0 833 663 A1

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(43) Date of publication: 08.04.1998 Bulletin 1998/15 (21) Application number: 96916458.0 (22) Date of filing: 13.05.1996

(51) International Patent Classification (IPC):  A61K 38/ 47( . ) A61K 39/ 385( . ) C07K 14/ 11( . ) C12P 21/ 08( . ) A61K 39/ 145( . ) A61K 47/ 48( . ) C07K 16/ 32( . ) (86) International application number: PCT/US1996/006756 (87) International publication number: WO 1996/036357 (21.11.1996 Gazette 1996/51)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.05.1995 US 19950441328 07.06.1995 US 19950477424 (71) Applicants: Bona, Constantin, A. New York, NY 10022 (US) Lee, Y., C. Timonium, MD 21093 (US) Brumeanu, Teodor-Doru New York, NY 10128 (US) Dehazya, Philip Port Jervis, NY 12771 (US)	(72) Inventors: Bona, Constantin, A. New York, NY 10022 (US) Lee, Y., C. Timonium, MD 21093 (US) Brumeanu, Teodor-Doru New York, NY 10128 (US) Dehazya, Philip Port Jervis, NY 12771 (US) (74) Representative: Symes, Christopher A., et al  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 80801 München 80801 München (DE)