(19)
(11) EP 0 835 106 A1

(12)

(43) Date of publication:
15.04.1998 Bulletin 1998/16

(21) Application number: 96921794.0

(22) Date of filing: 26.06.1996
(51) International Patent Classification (IPC): 
A61K 45/ 08( . )
A61K 31/ 401( . )
A61K 31/ 44( . )
A61P 13/ 02( . )
A61K 31/ 40( . )
A61K 31/ 415( . )
A61K 45/ 06( . )
A61P 15/ 00( . )
(86) International application number:
PCT/US1996/010942
(87) International publication number:
WO 1997/002032 (23.01.1997 Gazette 1997/05)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 30.06.1995 US 19950000770P
13.02.1996 GB 19960002854

(71) Applicants:
  • Merck & Co., Inc.
    Rahway New Jersey 07065-0900 (US)
  • LABORATOIRES MERCK SHARP & DOHME-CHIBRET SNC
    75008 Paris (FR)
  • Remuzzi, Giuseppe
    24129 Bergamo (IT)

(72) Inventors:
  • REMUZZI, Giuseppe
    I-24129 Bergamo (IT)
  • EYDELLOTH, Ronald, S.
    Rahway, NJ 07065 (US)
  • OWEN, Roger, A.
    F-75008 Paris (FR)
  • SHAHINFAR, Shahnaz
    Rahway, NJ 07065 (US)

(74) Representative: Hiscock, Ian James, et al 
European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) METHOD OF TREATING RENAL DISEASE USING AN ACE INHIBITOR AND AN AII ANTAGONIST