PYRIDINONE-THROMBIN INHIBITORS - Patent 0835109

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EP 0 835 109 A1

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(43)	Date of publication:
	15.04.1998 Bulletin 1998/16

(21)	Application number: 96923399.0

(22)	Date of filing: 24.06.1996

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International Patent Classification (IPC):

A61K 31/ 44^{( . )}
A61P 43/ 00^{( . )}
C07D 213/ 74^{( . )}
C07D 213/ 76^{( . )}
C07K 5/ 078^{( . )}

A61P 7/ 02^{( . )}
C07D 213/ 64^{( . )}
C07D 213/ 75^{( . )}
C07D 401/ 12^{( . )}

(86)	International application number:
	PCT/US1996/010778

(87)	International publication number:
	WO 1997/001338 (16.01.1997 Gazette 1997/04)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

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Priority:

27.06.1995 US 19950600560P
15.09.1995 US 19950603818P
19.02.1996 GB 19960003450

(71)	Applicant: MERCK & CO., INC.
	Rahway, New Jersey 07065 (US)

(72)	Inventors:
	SANDERSON, Philip, E. Rahway, NJ 07065 (US) NAYLOR-OLSEN, Adel, M. Rahway, NJ 07065 (US) DYER, Dona, L. Rahway, NJ 07065 (US) VACCA, Joseph, P. Rahway, NJ 07065 (US) ISAACS, Richard, C., A. Rahway, NJ 07065 (US) DORSEY, Bruce, D. Rahway, NJ 07065 (US) FRALEY, Mark, E. Rahway, NJ 07065 (US)

(74)	Representative: Horgan, James Michael Frederic, et al
	Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)

(54)	PYRIDINONE-THROMBIN INHIBITORS