(19)
(11) EP 0 835 111 A2

(12)

(43) Date of publication:
15.04.1998 Bulletin 1998/16

(21) Application number: 96923453.0

(22) Date of filing: 26.06.1996
(51) International Patent Classification (IPC): 
C07D 475/ 08( . )
A61K 31/ 40( . )
A61K 31/ 519( . )
A61K 31/ 7028( . )
A61K 31/ 7052( . )
A61K 33/ 24( . )
A61K 45/ 06( . )
A61P 43/ 00( . )
C07H 19/ 073( . )
A61K 31/ 17( . )
A61K 31/ 505( . )
A61K 31/ 70( . )
A61K 31/ 7042( . )
A61K 31/ 7064( . )
A61K 45/ 00( . )
A61P 35/ 00( . )
C07H 15/ 26( . )
C07H 19/ 09( . )
(86) International application number:
PCT/US1996/010921
(87) International publication number:
WO 1997/001344 (16.01.1997 Gazette 1997/04)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 27.06.1995 US 19950000546P
24.06.1996 US 19960668932

(71) Applicant: HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE
Rockville, MD 20852 (US)

(72) Inventors:
  • GRIMLEY, Philip, M.
    Potomac, MD 20854 (US)
  • MEHTA, Sunil
    Kensington, MD 20895 (US)

(74) Representative: Kolb, Helga, Dr. Dipl.-Chem., et al 
Hoffmann Eitle, Patent- und Rechtsanwälte, Arabellastrasse 4
81925 München
81925 München (DE)

   


(54) METHOD OF DYNAMIC RETARDATION OF CELL CYCLE KINETICS TO POTENTIATE CELL DAMAGE