(19)

(11)

EP 0 835 319 A1

(12)

(43) Date of publication: 15.04.1998 Bulletin 1998/16 (21) Application number: 96921006.0 (22) Date of filing: 28.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 35/ 76( . ) A61K 48/ 00( . ) C07K 14/ 47( . ) C07K 19/ 00( . ) C12N 15/ 12( . ) A61K 31/ 70( . ) A61K 38/ 00( . ) A61P 35/ 00( . ) C07K 14/ 82( . ) C12N 5/ 10( . ) C12N 15/ 83( . ) (86) International application number: PCT/GB1996/001560 (87) International publication number: WO 1997/002354 (23.01.1997 Gazette 1997/05)

(84) Designated Contracting States: AT BE CH DE DK FR GB IT LI NL SE (30) Priority: 30.06.1995 GB 19950013342 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventor: LaTHANGUE, Nicholas, Barrie University of Glasgow Davidson Bldg. Glasgow G12 8QQ (GB) (74) Representative: Brasnett, Adrian Hugh, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)