(19)

(11)

EP 0 835 323 A1

(12)

(43) Date of publication: 15.04.1998 Bulletin 1998/16 (21) Application number: 96922498.0 (22) Date of filing: 19.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 1/ 22( . ) C07K 19/ 00( . ) C12N 9/ 14( . ) C12N 9/ 22( . ) C12N 9/ 96( . ) C12N 15/ 62( . ) C12P 21/ 06( . ) C07K 1/ 107( . ) C07K 14/ 00( . ) C12N 9/ 12( . ) C12N 9/ 16( . ) C12N 9/ 24( . ) C12N 15/ 55( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1996/010545 (87) International publication number: WO 1997/001642 (16.01.1997 Gazette 1997/04)

(84) Designated Contracting States: DE FR GB (30) Priority: 28.06.1995 US 19950496247 29.12.1995 US 19950580555 (60) Divisional application: 05076460.4 / 1642980 (71) Applicant: NEW ENGLAND BIOLABS, INC. Beverly Massachusetts 01915 (US)

(72) Inventors: COMB, Donald, G. Manchester, MA 01944 (US) PERLER, Francine, B. Brookline, MA 02146 (US) JACK, William, E. Wenham, MA 01984 (US) XU, Ming-Qun Hamilton, MA 01982 (US) HODGES, Robert, A. Norcross, GA 30092 (US) NOREN, Christopher, J. Rockport, MA 01966 (US) CHONG, Shaorong, S., C. Beverly, MA 01915 (US) (74) Representative: Davies, Jonathan Mark  Reddie & Grose 16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)