(19)

(11)

EP 0 836 484 A1

(12)

(43) Date of publication: 22.04.1998 Bulletin 1998/17 (21) Application number: 96918243.0 (22) Date of filing: 05.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 48/ 00( . ) C12N 7/ 00( . ) C12N 15/ 864( . ) A61K 35/ 76( . ) C12N 5/ 10( . ) C12N 7/ 01( . ) (86) International application number: PCT/US1996/009263 (87) International publication number: WO 1996/040270 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950476018 (71) Applicant: The Research Foundation of State University of New York Stony Brook, NY 11794-3366 (US)	(72) Inventors: ZHOU, Xiaohuai Gainesville, FL 32608-2903 (US) MUZYCZKA, Nicholas Gainesville, FL 32608 (US) ZOLOTUKHIN, Sergei Gainesville, FL 32608-2580 (US) NI, Tiehua Malden, MA 02148 (US) (74) Representative: Jones, Helen Marjorie Meredith  Gill Jennings & Every, Broadgate House, 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)