(19)
(11) EP 0 836 599 A1

(12)

(43) Date of publication:
22.04.1998 Bulletin 1998/17

(21) Application number: 96921264.0

(22) Date of filing: 07.06.1996
(51) International Patent Classification (IPC): 
A61K 31/ 443( . )
A61K 31/ 495( . )
A61P 9/ 10( . )
A61P 25/ 06( . )
C07D 311/ 76( . )
C07D 405/ 06( . )
C07D 413/ 04( . )
A61K 31/ 445( . )
A61P 9/ 08( . )
A61P 25/ 04( . )
A61P 25/ 18( . )
C07D 405/ 04( . )
C07D 405/ 14( . )
(86) International application number:
PCT/US1996/008681
(87) International publication number:
WO 1997/002259 (23.01.1997 Gazette 1997/05)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
LV

(30) Priority: 30.06.1995 US 19950000741P
06.02.1996 US 19960011234P

(71) Applicant: PHARMACIA & UPJOHN COMPANY
Kalamazoo, Michigan 49001 (US)

(72) Inventors:
  • ENNIS, Michael, D.
    Portage, MI 49002 (US)
  • TENBRINK, Ruth, E.
    Richland, MI 49083 (US)

(74) Representative: Perry, Robert Edward 
GILL JENNINGS & EVERY Broadgate House 7 Eldon Street
London EC2M 7LH
London EC2M 7LH (GB)

   


(54) 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES