(19)

(11)

EP 0 836 604 A1

(12)

(43) Date of publication: 22.04.1998 Bulletin 1998/17 (21) Application number: 96921918.0 (22) Date of filing: 28.06.1996

(51) International Patent Classification (IPC):  A61K 31/ 435( . ) C07D 413/ 06( . ) C07D 487/ 08( . ) A61P 25/ 00( . ) C07D 453/ 02( . ) (86) International application number: PCT/DK1996/000294 (87) International publication number: WO 1997/001558 (16.01.1997 Gazette 1997/04)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 29.06.1995 DK 19950000757 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: OLESEN, Preben, H. DK-2400 Copenhagen NV (DK) HANSEN, John, Bondo DK-4450 Jyderup (DK)