(19)

(11)

EP 0 836 607 A1

(12)

(43) Date of publication: 22.04.1998 Bulletin 1998/17 (21) Application number: 96923404.0 (22) Date of filing: 24.06.1996

(51) International Patent Classification (IPC):  C07D 205/ 08( . ) C07F 7/ 18( . ) C07D 477/ 02( . ) (86) International application number: PCT/US1996/010783 (87) International publication number: WO 1997/001564 (16.01.1997 Gazette 1997/04)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 28.06.1995 US 19950000585P 13.02.1996 GB 19960002921 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: YANG, Chunhua Rahway, NJ 07065 (US) YASUDA, Nobuyoshi Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic, et al  Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)