(19)

(11)

EP 0 836 650 A1

(12)

(43) Date of publication: 22.04.1998 Bulletin 1998/17 (21) Application number: 96922662.0 (22) Date of filing: 03.07.1996

(51) International Patent Classification (IPC):  G01N 33/ 574( . ) C12Q 1/ 48( . ) G01N 33/ 15( . ) C12Q 1/ 02( . ) C12Q 1/ 68( . ) G01N 33/ 573( . ) (86) International application number: PCT/US1996/011330 (87) International publication number: WO 1997/002360 (23.01.1997 Gazette 1997/05)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.07.1995 US 19950000806P (71) Applicant: OREGON HEALTH SCIENCES UNIVERSITY Portland, OR 97201 (US)	(72) Inventors: RODLAND, Karin, D. Portland, OR 97221 (US) MCNEIL, Scott Portland, OR 97759 (US) MAGUN, Bruce Portland, OR 97221 (US) (74) Representative: Sexton, Jane Helen, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)