(19)

(11)

EP 0 837 857 A2

(12)

(43) Date of publication: 29.04.1998 Bulletin 1998/18 (21) Application number: 96911382.0 (22) Date of filing: 25.03.1996

(51) International Patent Classification (IPC):  C07K 5/ 02( . ) A61K 38/ 00( . ) C07K 5/ 078( . ) (86) International application number: PCT/US1996/003974 (87) International publication number: WO 1996/031525 (10.10.1996 Gazette 1996/45)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 29.03.1995 US A 412626 29.03.1995 US A 412828 13.02.1996 US A 600792 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventor: deSOLMS, S., Jane Rahway, NJ 07065 (US) (74) Representative: Thompson, John Dr.  Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)