(19)

(11)

EP 0 837 861 A1

(12)

(43) Date of publication: 29.04.1998 Bulletin 1998/18 (21) Application number: 96923481.0 (22) Date of filing: 03.07.1996

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 4353( . ) A61P 35/ 00( . ) A61K 31/ 435( . ) A61K 31/ 437( . ) C07D 495/ 16( . ) (86) International application number: PCT/US1996/010966 (87) International publication number: WO 1997/002267 (23.01.1997 Gazette 1997/05)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.07.1995 US 19950000887P 03.06.1996 US 19960018612P (71) Applicant: THE UNIVERSITY OF VERMONT Burlington, Vermont 05405-0160 (US)	(72) Inventor: KRAPCHO, A., Paul Shelburne, VT 05482 (US) (74) Representative: Weber, Manfred, Dr.  c/o Boehringer Mannheim GmbH, Patentabteilung, Sandhoferstrasse 116 68298 Mannheim 68298 Mannheim (DE)