(19)

(11)

EP 0 839 183 A1

(12)

(43) Date of publication: 06.05.1998 Bulletin 1998/19 (21) Application number: 96923904.0 (22) Date of filing: 24.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 00( . ) A61P 35/ 00( . ) C12N 5/ 10( . ) C12P 21/ 08( . ) G01N 33/ 574( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) C07K 16/ 30( . ) C12N 15/ 02( . ) G01N 33/ 53( . ) (86) International application number: PCT/EP1996/002747 (87) International publication number: WO 1997/000946 (09.01.1997 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.06.1995 EP 19950109860 (71) Applicant: Micromet GmbH 82152 Planegg (DE)	(72) Inventors: DICKMANNS, Achim D-85649 Hofolding (DE) FANNING, Ellen, Vanderbilt University Nashville, TN 37235 (US) PANTEL, Klaus D-85386 Eching (DE) RIETHMÜLLER, Gerhard D-80805 München (DE) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)