(19)

(11)

EP 0 840 614 A1

(12)

(43) Date of publication: 13.05.1998 Bulletin 1998/20 (21) Application number: 95922312.0 (22) Date of filing: 13.06.1995

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) C07C 229/ 00( . ) C07K 5/ 06( . ) A61K 38/ 06( . ) C07K 5/ 00( . ) C07K 5/ 078( . ) (86) International application number: PCT/US1995/007463 (87) International publication number: WO 1996/041638 (27.12.1996 Gazette 1997/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: SANOFI WINTHROP, INC. New York, NY 10016 (US)	(72) Inventors: DOLLE, Roland, E. King of Prussia, PA 19406 (US) GRAYBILL, Todd, L. Pottstown, PA 19465 (US) OSIFO, Irennegbe, K. W. Norristown, PA 19403-2646 (US) HARRIS, Alex, L. Carlsbad, CA 92009 (US) MILLER, Matthew, S. Newtown, PA 18940 (US) (74) Representative: White, Martin Paul, et al  Kilburn & Strode, 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)