(19)

(11)

EP 0 840 725 A1

(12)

(43) Date of publication: 13.05.1998 Bulletin 1998/20 (21) Application number: 96922030.0 (22) Date of filing: 20.06.1996

(51) International Patent Classification (IPC):  C07D 205/ 09( . ) A61K 31/ 427( . ) A61P 9/ 10( . ) C07D 205/ 085( . ) C07D 401/ 12( . ) C07D 405/ 12( . ) C07D 417/ 12( . ) A61K 31/ 397( . ) A61K 31/ 4427( . ) C07D 205/ 08( . ) C07D 205/ 095( . ) C07D 405/ 06( . ) C07D 409/ 12( . ) (86) International application number: PCT/EP1996/002765 (87) International publication number: WO 1997/002242 (23.01.1997 Gazette 1997/05)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 01.07.1995 GB 19950013442 22.07.1995 GB 19950015056 25.07.1995 GB 19950015206 18.08.1995 GB 19950016985 08.12.1995 GB 19950025132 26.04.1996 GB 19960008651 26.04.1996 GB 19960008650 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)

(72) Inventors: DHANAK, Dashyant, SmithKline Beecham Pharma. Welwyn, Hertfordshire AL6 9AR (GB) HICKEY, Deirdre, M.B., SmithKline Beecham Pharma. Welwyn, Hertfordshire AL6 9AR (GB) IFE, Robert, J., SmithKline Beecham Pharmaceuticls Welwyn, Hertfordshire AL6 9AR (GB) LEACH, Colin, A., SmithKline Beecham Pharma. Welwyn, Hertfordshire AL6 9AR (GB) TEW, David, G., SmithKline Beecham Pharmaceuticals Welwyn, Hertfordshire AL6 9AR (GB) (74) Representative: Connell, Anthony Christopher, et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)