(19)

(11)

EP 0 840 739 A1

(12)

(43) Date of publication: 13.05.1998 Bulletin 1998/20 (21) Application number: 96923232.0 (22) Date of filing: 05.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12Q 1/ 68( . ) G01N 33/ 566( . ) A61K 31/ 70( . ) G01N 33/ 53( . ) (86) International application number: PCT/US1996/009455 (87) International publication number: WO 1996/040703 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950479724 07.06.1995 US 19950472256 07.06.1995 US 19950472255 07.06.1995 US 19950477829 (71) Applicant: NeXstar Pharmaceuticals, Inc. Boulder, CO 80301 (US)	(72) Inventors: PARMA, David, H. Boulder, CO 80301 (US) HICKE, Brian Boulder, CO 80303 (US) BRIDONNEAU, Philippe Boulder, CO 80303 (US) GOLD, Larry Boulder, CO 80302 (US) (74) Representative: Lucas, Brian Ronald, et al  Lucas & Co. 135 Westhall Road Warlingham Surrey CR6 9HJ Warlingham Surrey CR6 9HJ (GB)