PROCESS FOR PROTEIN REFOLDING BY MEANS OF BUFFER EXCHANGE USING A CONTINUOUS STATIONARY PHASE CAPABLE OF SEPARATING PROTEINS FROM SALT - Patent 0840745

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EP 0 840 745 A2

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(43)	Date of publication:
	13.05.1998 Bulletin 1998/20

(21)	Application number: 96925295.0

(22)	Date of filing: 11.07.1996

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International Patent Classification (IPC):

C07K 1/ 113^{( . )}
C07K 14/ 475^{( . )}
C07K 14/ 81^{( . )}

C07K 1/ 14^{( . )}
C07K 14/ 48^{( . )}

(86)	International application number:
	PCT/US1996/011581

(87)	International publication number:
	WO 1997/004003 (06.02.1997 Gazette 1997/07)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV SI

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Priority:

21.07.1995 US 19950505420

(71)	Applicants:
	AMGEN INC. Thousand Oaks, CA 91320-1789 (US) PURDUE RESEARCH FOUNDATION West Lafayette, IN 47907-1650 (US)

(72)	Inventors:
	SEELY, Robert J. Loveland, CO 80538 (US) LADISCH, Michael R. West Lafayette, IN 47906 (US)

(74)	Representative: Brown, John David, et al
	FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 80801 München 80801 München (DE)

(54)	PROCESS FOR PROTEIN REFOLDING BY MEANS OF BUFFER EXCHANGE USING A CONTINUOUS STATIONARY PHASE CAPABLE OF SEPARATING PROTEINS FROM SALT