(19)

(11)

EP 0 840 787 A2

(12)

(43) Date of publication: 13.05.1998 Bulletin 1998/20 (21) Application number: 96945463.0 (22) Date of filing: 20.06.1996

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 45/ 00( . ) A61P 29/ 00( . ) C07K 16/ 28( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) G01N 33/ 566( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) C07K 14/ 705( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1996/010618 (87) International publication number: WO 1997/000952 (09.01.1997 Gazette 1997/03)

(84) Designated Contracting States: BE DE ES FR GB IT NL (30) Priority: 20.06.1995 US 19950000352P 06.12.1995 US 19950567817 (71) Applicant: INCYTE PHARMACEUTICALS, INC. Palo Alto , CA 94304 (US)	(72) Inventor: SEILHAMER, Jeffrey J. Los Altos Hills, CA 94022 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)