(19)

(11)

EP 0 840 796 A2

(12)

(43) Date of publication: 13.05.1998 Bulletin 1998/20 (21) Application number: 96924664.0 (22) Date of filing: 19.07.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 17( . ) A61K 39/ 118( . ) A61K 48/ 00( . ) A61P 37/ 02( . ) A61K 31/ 00( . ) A61K 38/ 28( . ) A61K 47/ 48( . ) A61P 37/ 00( . ) C12N 15/ 87( . ) (86) International application number: PCT/US1996/012041 (87) International publication number: WO 1997/005267 (13.02.1997 Gazette 1997/08)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.07.1995 US 19950001527P (71) Applicant: Maxim Pharmaceuticals San Diego, CA 92121 (US)	(72) Inventor: KING, Dannie, H. Rancho Santa Fe, CA 92067 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)