(19)

(11)

EP 0 842 187 A1

(12)

(43) Date of publication: 20.05.1998 Bulletin 1998/21 (21) Application number: 95922973.0 (22) Date of filing: 05.06.1995

(51) International Patent Classification (IPC):  C07K 14/ 81( . ) A61K 48/ 00( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1995/007135 (87) International publication number: WO 1996/039418 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: NI, Jian Rockville, MD 20853 (US) YU, Guo-Liang Darnestown, MD 20878 (US) GENTZ, Reiner Silver Spring, MD 20904 (US) ROSEN, Craig, A. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)