(19)

(11)

EP 0 842 274 A1

(12)

(43) Date of publication: 20.05.1998 Bulletin 1998/21 (21) Application number: 96928406.0 (22) Date of filing: 02.08.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) A61P 1/ 02( . ) A61P 19/ 10( . ) C07K 14/ 51( . ) C12P 21/ 02( . ) A61K 31/ 00( . ) A61P 1/ 00( . ) A61P 19/ 00( . ) C07K 14/ 495( . ) C12N 15/ 12( . ) (86) International application number: PCT/EP1996/003427 (87) International publication number: WO 1997/006254 (20.02.1997 Gazette 1997/09)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 03.08.1995 EP 19950112241 (71) Applicant: BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH 69115 Heidelberg (DE)	(72) Inventors: KIMURA, Michio Sakado-shi, Saitama 350-02 (JP) MATSUMOTO, Tomoaki Kawagoe-shi, Saitama 356 (JP) TAKAHASHI, Mikiko Hasuda-shi, Saitama 349-01 (JP) KAWAI, Shinji Iruma-gun, Saitama 356 (JP) FUJINO, Yukio Tokorozawa-shi, Saitama 359 (JP) (74) Representative: Böhm, Brigitte, Dipl.-Chem. Dr.  Postfach 86 08 20 81635 München 81635 München (DE)